The Substance

The Substance is a 2024 body horror film written and directed by Coralie Fargeat. It follows a fading celebrity (Demi Moore) who is fired by her producer (Dennis Quaid) due to her age and uses a black market drug that creates a younger version of herself (Margaret Qualley) with unexpected side effects. Fargeat wrote the screenplay to explore societal pressures surrounding women's bodies and aging. Principal photography took place in France from August to October 2022.